原创力文档role of novelty seeking personality traits as mediator of the association between comt and onset age of drug use in chinese heroin dependent patients追求新奇的个性角色的中介联系comt和发病年龄在中国海洛因依赖患者药物使用.pdfVIP
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role of novelty seeking personality traits as mediator of the association between comt and onset age of drug use in chinese heroin dependent patients追求新奇的个性角色的中介联系comt和发病年龄在中国海洛因依赖患者药物使用
Role of Novelty Seeking Personality Traits as Mediator of
the Association between COMT and Onset Age of Drug
Use in Chinese Heroin Dependent Patients
1. 1. 1 1 1 2 1
Ting Li , Shunying Yu , Jiang Du , Hanhui Chen , Haifeng Jiang , Ke Xu , Yingmei Fu , Dongxiang
1 1
Wang , Min Zhao *
1 Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China, 2 Department of Psychiatry, School of Medicine, Yale University,
New Haven, Connecticut, United States of America
Abstract
Background: Personality traits such as novelty seeking (NS) are associated with substance dependence but the mechanism
underlying this association remains uncertain. Previous studies have focused on the role of the dopamine pathway.
Objective: Examine the relationships between allelic variants of the catechol-O- methlytransferase (COMT) gene, NS
personality traits, and age of onset of drug use in heroin-dependent subjects in China.
Methods: The 478 heroin dependent subjects from four drug rehabilitation centers in Shanghai who were genotyped for
eight tagging single nucleotide polymorphisms (SNP) on the COMT gene completed the NS subscale from the
Temperament and Character Inventory. Multivaritate analyses were used to assess the potential mediating role of NS
personality traits in the association between COMT gene variants and the age of onset of heroin use.
Principal Findings and Conclusions: In the univariate analysis the COMT rs737866 gene variants were independently
associated with both NS and age of onset of drug use: those with the TT genotype had higher NS subscale scores and an
earlier onset age of
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