sequencing of disc1 pathway genes reveals increased burden of rare missense variants in schizophrenia patients from a northern swedish populationdisc1通路基因的测序揭示负担增加罕见的错义变体在精神分裂症患者从瑞典北部的人口.pdfVIP

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sequencing of disc1 pathway genes reveals increased burden of rare missense variants in schizophrenia patients from a northern swedish populationdisc1通路基因的测序揭示负担增加罕见的错义变体在精神分裂症患者从瑞典北部的人口.pdf

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sequencing of disc1 pathway genes reveals increased burden of rare missense variants in schizophrenia patients from a northern swedish populationdisc1通路基因的测序揭示负担增加罕见的错义变体在精神分裂症患者从瑞典北部的人口

Sequencing of DISC1 Pathway Genes Reveals Increased Burden of Rare Missense Variants in Schizophrenia Patients from a Northern Swedish Population Lotte N. Moens1,2, Peter De Rijk1,2, Joke Reumers3,4, Maarten J. A. Van Den Bossche1,2, Wim Glassee1,2, 1,2 1,2 5 ¨ 6 7 Sonia De Zutter , An-Sofie Lenaerts , Annelie Nordin , Lars-Goran Nilsson , Ignacio Medina Castello , 5 1,2 8 5 1,2 Karl-Fredrik Norrback , Dirk Goossens , Kristel Van Steen , Rolf Adolfsson , Jurgen Del-Favero * 1 Applied Molecular Genomics Group, Department of Molecular Genetics, Flanders Institute for Biotechnology (VIB), Flanders, Belgium, 2 University of Antwerp (UA), Antwerp, Belgium, 3 SWITCH Laboratory, Flanders Institute for Biotechnology (VIB), Flanders, Belgium, 4 Vrije Universiteit Brussel (VUB), Brussels, Belgium, 5 Division of ˚ ˚ Psychiatry, Department of Clinical Sciences, Umea University, Umea, Sweden, 6 Department of Psychology, Stockholm University, Stockholm, Sweden, 7 Functional Genomics Unit, Bioinformatics and Genomics Department, Prince Felipe Research Centre (CIPF), Valencia, Spain, 8 Systems and Modeling Unit, Montefiore Institute/GIGA, ` ` University of Liege, Liege, Belgium Abstract In recent years, DISC1 has emerged as one of the most credible and best supported candidate genes for schizophrenia and related neuropsychiatric disorders. Furthermore, increasing evidence – both genetic and functional – indicates that many of