原创力文档sdf1 gene variation is associated with circulating sdf1α level and endothelial progenitor cell number–the bruneck studysdf1基因变异与循环内皮祖细胞竞赛bruneck sdf1α水平和研究.pdfVIP
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sdf1 gene variation is associated with circulating sdf1α level and endothelial progenitor cell number–the bruneck studysdf1基因变异与循环内皮祖细胞竞赛bruneck sdf1α水平和研究
SDF1 Gene Variation Is Associated with Circulating
SDF1a Level and Endothelial Progenitor Cell Number–
The Bruneck Study
1 2 3 3 4 5
Qingzhong Xiao , Shu Ye , Friedrich Oberhollenzer , Agnes Mayr , Marjan Jahangiri , Johann Willeit ,
5 1
Stefan Kiechl , Qingbo Xu *
1 Cardiovascular Division, King’s College London BHF Centre, London, United Kingdom, 2 Barts and the London School of Medicine and Dentistry, Queen Mary University
of London, London, United Kingdom, 3 Department of Internal and Laboratory Medicine, Bruneck Hospital, Bruneck, Italy, 4 Department of Cardiothoracic Surgery, St.
George’s Hospital, London, United Kingdom, 5 Department of Neurology, Medical University of Innsbruck, Innsbruck, Austria
Abstract
Background: Stromal cell-derived factor-1 (SDF1) and its receptor CXC chemokine receptor 4 (CXCR4) play a critical role in
progenitor cell homing, mobilization and differentiation. It would be interesting to assess the predictive value of SDF-1alpha
level for EPC number, and to ascertain whether there is a relationship between SDF1 gene variation, plasma SDF-1alpha
level, and the number and function of circulating EPCs. We also tested whether EPC number and function was related to
CXCR4 gene variation.
Methodology and Principal Findings: We genotyped a cohort of individuals who participated in the Bruneck Study for
single nucleotide polymorphisms (SNPs) in the SDF1 and CXCR4 genes, and measured blood SDF1a level as well as EPC
number and function. SDF1a levels were correlated with age, gender, alcohol consumption, circulating reticulocyte
numbers, and concentrations of matrix metalloproteinase-9, C-reactive protein, cystatin C, fibrinogen and homocytein. I
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