原创力文档role of the dopaminergic system in the acquisition, expression and reinstatement of mdma-induced conditioned place preference in adolescent mice收购的多巴胺能系统的作用,表达和恢复mdma-induced条件性位置偏爱在青少年老鼠.pdfVIP
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role of the dopaminergic system in the acquisition, expression and reinstatement of mdma-induced conditioned place preference in adolescent mice收购的多巴胺能系统的作用,表达和恢复mdma-induced条件性位置偏爱在青少年老鼠
Role of the Dopaminergic System in the Acquisition,
Expression and Reinstatement of MDMA-Induced
Conditioned Place Preference in Adolescent Mice
´ ´ ´ ´ ˜
Antonio Vidal-Infer, Concepcion Roger-Sanchez, Manuel Daza-Losada, Marıa A. Aguilar, Jose Minarro,
´
Marta Rodrıguez-Arias*
Unit of Research on Psychobiology of Drug Dependence, University of Valencia, Valencia, Spain
Abstract
Background: The rewarding effects of 3,4-methylenedioxy-metamphetamine (MDMA) have been demonstrated in
conditioned place preference (CPP) procedures, but the involvement of the dopaminergic system in MDMA-induced CPP
and reinstatement is poorly understood.
Methodology/Principal Findings: In this study, the effects of the DA D1 antagonist SCH 23390 (0.125 and 0.250 mg/kg), the
DA D2 antagonist Haloperidol (0.1 and 0.2 mg/kg), the D2 antagonist Raclopride (0.3 and 0.6 mg/kg) and the dopamine
release inhibitor CGS 10746B (3 and 10 mg/kg) on the acquisition, expression and reinstatement of a CPP induced by
10 mg/kg of MDMA were evaluated in adolescent mice. As expected, MDMA significantly increased the time spent in the
drug-paired compartment during the post-conditioning (Post-C) test, and a priming dose of 5 mg/kg reinstated the
extinguished preference. The higher doses of Haloperidol, Raclopride and CGS 10746B and both doses of SCH 23390
blocked acquisition of the MDMA-induced CPP. However, only Haloperidol blocked expression of the CPP. Reinstatement of
the extinguished preference was not affected by any of the drugs studied. Analysis of brain monoamines revealed that the
blockade of CPP acquis
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