scribble acts in the drosophila fat-hippo pathway to regulate warts activity潦草的果蝇fat-hippo通路中的行为规范疣活动.pdfVIP

Scribble Acts in the Drosophila Fat-Hippo Pathway to Regulate Warts Activity 1 1 1 1 1,2,3 Shilpi Verghese , Indrayani Waghmare , Hailey Kwon , Katelin Hanes , Madhuri Kango-Singh * 1 Department of Biology, University of Dayton, Dayton, Ohio, United States of America, 2 Pre-Medical Programs, University of Dayton, Dayton, Ohio, United States of America, 3 Center for Tissue Regeneration and Engineering at Dayton, University of Dayton, Dayton, Ohio, United States of America Abstract Epithelial cells are the major cell-type for all organs in multicellular organisms. In order to achieve correct organ size, epithelial tissues need mechanisms that limit their proliferation, and protect tissues from damage caused by defective epithelial cells. Recently, the Hippo signaling pathway has emerged as a major mechanism that orchestrates epithelial development. Hippo signaling is required for cells to stop proliferation as in the absence of Hippo signaling tissues continue to proliferate and produce overgrown organs or tumors. Studies in Drosophila have led the way in providing a framework for how Hippo alters the pattern of gene transcription in target cells, leading to changes in cell proliferation, survival, and other behaviors. Scribble (Scrib) belongs to a class of neoplastic tumor suppressor genes that are required to establish apical-basal cell polarity. The disruption of apical-basal polarity leads to uncontrolled cell proliferation of epithelial cells. The interaction of apical basal polarity genes with the Hippo pathway has been an area of intense investigation. Loss of scrib has been known to affect Hippo pathway targets, howe