serum acylated ghrelin is negatively correlated with the insulin resistance in the coding study血清acylated ghrelin负相关与胰岛素抵抗在编码的研究.pdfVIP

Serum Acylated Ghrelin Is Negatively Correlated with the Insulin Resistance In the CODING study 1 1 1 2 1 3 Peyvand Amini , Danny Wadden , Farrell Cahill , Edward Randell , Sudesh Vasdev , Xihua Chen , 1 4 1 1 1 Wayne Gulliver , Weizhen Zhang , Hongwei Zhang , Yanqing Yi , Guang Sun * 1 Division of Medicine, Memorial University of Newfoundland, St. John’s, Newfoundland and Labrador, Canada, 2 Discipline of Laboratory Medicine, Memorial University of Newfoundland, St. John’s, Newfoundland and Labrador, Canada, 3 Division of BioMedical Sciences, Memorial University of Newfoundland, St. John’s, Newfoundland and Labrador, Canada, 4 Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Peking University, Beijing, People’s Republic of China Abstract Objective: Ghrelin is a 28-amino acid orexigenic peptide synthesized mainly in the stomach. Acute administration of ghrelin has been found to decrease insulin secretion. However, little data is available regarding whether ghrelin contributes to the long-term regulation of insulin resistance at the population level. The aim of this study is to investigate the association between circulating ghrelin and insulin resistance in a large population based study. Design: A total of 2082 CODING study (Complex Diseases in the Newfoundland population: Environment and Genetics) subjects were assessed. Subjects were of at least third generation Newfoundland descent, between the ages of 20 and 79 years, and had no serious metabolic, cardiovascular, or endocrine diseases. Ghrelin was measured with an Enzyme Immunoassay method.