原创力文档sex differences in the association between serum levels of testosterone and frailty in an elderly population the toledo study for healthy aging血清睾酮水平之间的关系的性别差异和虚弱的老年人口健康老龄化的托莱多的研究.pdfVIP
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sex differences in the association between serum levels of testosterone and frailty in an elderly population the toledo study for healthy aging血清睾酮水平之间的关系的性别差异和虚弱的老年人口健康老龄化的托莱多的研究
Sex Differences in the Association between Serum Levels
of Testosterone and Frailty in an Elderly Population: The
Toledo Study for Healthy Aging
1 2 ´ 3 4 ´
Laure Carcaillon *, Carmen Blanco , Cristina Alonso-Bouzon , Ana Alfaro-Acha , Francisco-Jose Garcia-
´ 4 ˜ 1,3
Garcıa , Leocadio Rodriguez-Manas *
´ ´ ´ ´
1 Fundacion para la Investigacion Biomedica, Hospital Universitario de Getafe, Madrid, Spain, 2 Servicio de Analisis Clinicos, Hospital Universitario de Getafe, Madrid, Spain,
´ ´
3 Servicio de Geriatrıa, Hospital Universitario de Getafe, Madrid, Spain, 4 Servicio de Geriatrıa, Hospital Virgen del Valle, Complejo Hospitalario de Toledo, Toledo, Spain
Abstract
Background: Age-associated decline in testosterone levels represent one of the potential mechanisms involved in the
development of frailty. Although this association has been widely reported in older men, very few data are available in
women. We studied the association between testosterone and frailty in women and assessed sex differences in this
relationship.
Methods: We used cross-sectional data from the Toledo Study for Healthy Aging, a population-based cohort study of
Spanish elderly. Frailty was defined according to Fried’s approach. Multivariate odds-ratios
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