原创力文档superhelical destabilization in regulatory regions of stress response genes超螺旋监管地区不稳定的应激反应基因.pdfVIP
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superhelical destabilization in regulatory regions of stress response genes超螺旋监管地区不稳定的应激反应基因
Superhelical Destabilization in Regulatory
Regions of Stress Response Genes
*
Huiquan Wang, Craig J. Benham
UC Davis Genome Center, University of California Davis, Davis, California, United States of America
Stress-induced DNA duplex destabilization (SIDD) analysis exploits the known structural and energetic properties of
DNA to predict sites that are susceptible to strand separation under negative superhelical stress. When this approach
was used to calculate the SIDD profile of the entire Escherichia coli K12 genome, it was found that strongly
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