奥美拉唑（omeprazole）.docVIP

奥美拉唑（omeprazole） Rational clinical use of omeprazole and its adverse reactions and interactions A new generation of proton pump inhibitors, omeprazole, is a new type of anti peptic ulcer drug that selectively inhibits the gastric H+-K+-ATP enzyme (proton pump), thereby preventing the last link of gastric acid secretion. Gastric acid can exert a strong inhibitory effect on basic gastric acid and other forms of stress. Because of its remarkable curative effect, low recurrence rate and convenient application, it is widely used in clinic. As applications spread, adverse reactions and interactions also occur frequently. Not long ago, the State Food and drug administration put forward the notice of modifying the instructions of omeprazole. At this point, I consulted the relevant literature, clinical application of omeprazole, adverse reactions, drug interaction summarized as follows, and we discuss the study together. 1. clinical application of omeprazole 1.1 mechanism of action: The acidic environment after the application of omeprazole accumulation in the cell wall of the secretory canaliculus, can be combined with H+-K+-ATP enzyme thiol specific reduced its activity, thereby blocking the last link of wall cells secrete hydrochloric acid, can release H+ cells, gastric acid PH increased significantly. In addition, it can also improve the gastric mucosal potential, maintain the stability of gastric cells, protect the gastric mucosal barrier, and facilitate the repair and hemostasis of the mucosa of gastroduodenal lesions. In addition, omeprazole on histamine, gastrin and five vagus nerve stimulation induced gastric acid secretion also significantly inhibited, H2 receptor antagonists can inhibit the growth of the two butyl caused by cyclic AMP gastric acid secretion also had a strong and lasting inhibition. 1.2, reasonable application: Long term application can cause excessive growth of gastric bacteria, nitrite and N-, nitrite increased significantly, plasma gastrin level