第十三十五章 细胞返闹化、干细胞.pptVIP

第十三章 细胞分化;二、特点 时空性：细胞分化潜能随个体发育逐渐变小，与细胞分裂密切相关 细胞分裂次数 ↑ 细胞分化能力 ↓ 稳定性：保持分化后细胞结构和功能的稳定，遗传的稳定性 可逆性和全能性：受细胞周围环境影响 克隆羊试验 注：少数细胞遗传物质丢失—终末细胞（不可逆） ;细胞分化的时空性;间介中胚层和侧中胚层的分化;Evaluation only. Created with Aspose.Slides for .NET 3.5 Client Profile 5.2.0.0. Copyright 2004-2011 Aspose Pty Ltd.;二、 细胞分化的决定因素;2. 基因选择表达决定细胞分化;Evaluation only. Created with Aspose.Slides for .NET 3.5 Client Profile 5.2.0.0. Copyright 2004-2011 Aspose Pty Ltd.;Evaluation only. Created with Aspose.Slides for .NET 3.5 Client Profile 5.2.0.0. Copyright 2004-2011 Aspose Pty Ltd.;（1）同源盒基因排列顺序决定个体发育和细胞分化;Evaluation only. Created with Aspose.Slides for .NET 3.5 Client Profile 5.2.0.0. Copyright 2004-2011 Aspose Pty Ltd.;珠蛋白基因甲基化与基因表达调控;（2）染色质结构与修饰决定细胞分化 DNA的缺失、重排、甲基化修饰 组蛋白的乙酰化、甲基化、磷酸化 分化主导基因表达控制 ;Evaluation only. Created with Aspose.Slides for .NET 3.5 Client Profile 5.2.0.0. Copyright 2004-2011 Aspose Pty Ltd.;人类主要组织相容性复合体（MHC）基因 ; ;TCR β链基因重排; 三、细胞分化的影响因素 ;（一）细胞间相互作用; 胚胎诱导的分子基础是旁分泌此外，相互之间的连接及基质，甚至挤压也会影响胚胎发育;Evaluation only. Created with Aspose.Slides for .NET 3.5 Client Profile 5.2.0.0. Copyright 2004-2011 Aspose Pty Ltd.;Evaluation only. Created with Aspose.Slides for .NET 3.5 Client Profile 5.2.0.0. Copyright 2004-2011 Aspose Pty Ltd.;Evaluation only. Created with Aspose.Slides for .NET 3.5 Client Profile 5.2.0.0. Copyright 2004-2011 Aspose Pty Ltd.;第二节 细胞分化与疾病;一、 细胞分化与肿瘤;二、细胞分化与再生;再生的分类;参与再生过程的细胞;第十五章 干细胞;一、 干细胞的分类 ;Evaluation only. Created with Aspose.Slides for .NET 3.5 Client Profile 5.2.0.0. Copyright 2004-2011 Aspose Pty Ltd.;二、干细胞的形态及生化特征;三、增殖特征;Evaluation only. Created with Aspose.Slides for .NET 3.5 Client Profile 5.2.0.0. Copyright 2004-2011 Aspose Pty Ltd.;Evaluation only. Created with Aspose.Slides for .NET 3.5 Client Profile 5.2.0.0. Copyright 2004-2011 Aspose Pty Ltd.;四、分化特征;Evaluation only. Created with Aspose.Slides for .NET 3.5 Client Profile 5.2.0.0. Copyright 2004-2011 Aspose Pty Ltd.;五、干细胞微环境;Evaluation only. Created with Aspose.Slides for .NET 3.5 Client Profile