2型糖尿病患者血浆Apelin12水平及高血压、胰岛素抵抗相关性.docVIP

2型糖尿病患者血浆Apelin12水平及高血压、胰岛素抵抗相关性 　 作者：郑天鹏 郭常辉 周婷婷 罗叶晰 赵璇 张晓娟 蒋文娟 【摘要】 目的 探讨Apelin12与高血压、肥胖、胰岛素抵抗、炎症等的相关性。方法 测定31例单纯2型糖尿病、37例2型糖尿病合并高血压患者及25例健康对照者血浆Apelin12、肿瘤坏死因子α(TNFα)、血脂、糖化血红蛋白(HbA1c)、空腹血糖、空腹胰岛素(FINS)、胰岛素抵抗(IR)指数(HOMAIR)、体重指数(BMI)、血压等水平并进行各参数之间的相关分析。结果 ①糖尿病合并高血压组血浆Apelin12水平低于正常对照组和单纯糖尿病组(Plt;0.05或Plt;0.01),单纯糖尿病组血浆Apelin12水平高于正常对照组(Plt;0.05)。②糖尿病合并高血压组TNFα水平高于糖尿病组和正常对照组(Plt;0.05或Plt;0.01)，糖尿病组TNFα水平高于正常对照组(Plt;0.05)③直线相关分析显示，空腹血浆Apelin12与腰臀比(WHR),FINS，HOMAIR，甘油三酯(TG),收缩压(SBP)，TNFα呈负相关,与HDLC呈正相关。结论 血浆Apelin12水平在糖尿病组升高，在糖尿病合并高血压组降低，且与肥胖、IR、炎症等相关。推测Apelin12可能参与了IR、2型糖尿病、高血压等疾病的发生 发展 。 毕业论文 【关键词】 Apelin12;TNFα;2型糖尿病;高血压;胰岛素抵抗 论文代写 　　【Abstract】 Objective To investigate the relationship between plasma apelin12 level and hypertension, obesity, insulin resistance(IR), inflammation of type 2 diabetes mellitus(T2DM). Methods 25 healthy subjects of control group, 30 T2DM patients, 38 patients with T2DM and hypertension were selected. The plasma levels of apelin12, tumor necrosis factorα(TNFα), blood fat, glycosylated hemoglobin(HbA1c), fasting plasma glucose, fasting insulin level, IR index(HOMAIR), body mass index(BMI) and blood pressure were measured in each group. Data were analyzed by variable correlation. Results ① The apelin12 levels in patients with T2DM and hypertension were significantly lower than that in control and T2DM groups(Plt;0.05 or Plt;0.01),the apelin12 level of patients with T2DM group was higher than that in control group (Plt;0.05).②TNFα levels in patients with T2DM and hypertension was significantly higher than that in control and T2DM groups(Plt;0.05 or Plt;0.01),TNFα level of patients with T2DM only was significantly higher than that in control group(Plt;0.05).③There were negative correlation between the plasma apelin12 level and WHR, FINS, HOMAIR, TG, SBP, TNFα,and positive correlation between it and the HDLC. WHR, HOMAIR, TG, TNFα were equal predicators of plasma apelin12 level. Conclusions The p