冬凌草甲素对人鼻咽癌细胞株CNE2细胞放射增敏作用.docVIP

冬凌草甲素对人鼻咽癌细胞株CNE2细胞放射增敏作用 　 【关键词】 冬凌草甲素 鼻咽肿瘤 放射增敏 A［ABSTRACT］ Objective: To observe the radiosensitization of Oridonin and its mechanism on nasopharyngeal carcinoma cell line CNE2. Methods： The radiation sensitization enhancement ratio（SER） was determined by clonogenic assay. Cell cycle distribution was assessed by flow cytometry. Results： The SER was 1.227. The rate of G2/M phase block related to the Oridonin group, the radiotherapy group and the combination treatment group was 17.8%, 24.7% and 45.2%, respectively. Conclusion： Oridonin can enhance radiosensitition for CNE2 cells, w