同型半胱氨酸及脑卒中类型、病变部位、程度相关性探究.docVIP

同型半胱氨酸及脑卒中类型、病变部位、程度相关性探究 　 ; 作者：林晓东，赵丽，李福学，王学敏，孔丽清，宗润华，朱静，王虹，王素珍，王海英 毕业论文 【关键词】; ,脑卒中；同型半胱氨酸；病变部位；病变程度 毕业论文 　　［摘要］; 目的; 研究血浆同型半胱氨酸（Hcy）与不同卒种类型、病变部位、病变程度的关系。方法; 采用荧光偏振免疫分析方法测定250例脑卒中患者和130例健康者血浆Hcy水平，病例组同时记录神经功能缺损评分、血压、血糖、血脂，并进行多元线性回归分析。结果; 病例组与对照组的血浆Hcy水平差异有显著性（Plt;0.05），病例组高于对照组。病例组做血压、血糖、血脂、Hcy多元线性回归分析，Hcy与神经功能缺损评分存在线性关系。无论病灶位于基底节、脑叶还是脑干，其Hcy水平差异均无显著性（Pgt;0.05）。结论; 急性脑卒中患者血浆Hcy水平反映病情的严重程度，有助于评估预后，指导临床治疗。 毕业论文 　　［关键词］; 脑卒中；同型半胱氨酸；病变部位；病变程度 毕业论文 　　Relativity of the type and location and grade of stroke with the serum homocysteine level 毕业论文 　　［Abstract］; Objective; To study the relativity of the type and location and grade of stroke with the serum homocysteine level.Methods; Plasma Hcy levels of 250 cases of stroke and 130 healthy subjects were measured by using immuno-fluorescence polarization.Meanwhile，the evaluation of their clinical neurological dysfunction scale were recorded and the blood pressure，blood sugar and blood lipid of patients in the case group were measured，which was followed by multiple linear regression analysis on blood pressure，blood sugar，blood lipid and plasma Hcy level.Results; Plasma Hcy level in the patients was significantly higher than that in the controls(Plt;0.05). Multiple linear regression analysis in the case group showed that when blood pressure，blood sugar，blood lipid and plasma Hcy were considered，linear relationship could only be found between Hcy level and grade of stroke.There was no significant difference between basal ganglia，cerebral lobe，brain stem(Pgt;0.05).Conclusion; Plasma Hcy level in patients with stroke may reflect the severity of patients.It helps to evaluate the prognosis of the patient and may have some significance in guiding the clinical treatment. 毕业论文 　　［Key words］; stroke;homocysteine;location;grade 毕业论文 　　流行病学调查和临床研究认为，高同型半胱氨酸血症与动脉粥样硬化、脑卒中的发病有关，是脑卒中的一个新的独立的和重要的危险因素，但也有少数文献指出与脑卒中的发病无关，而是一个伴发因素。本课题采用前瞻性方法测定250例不同类型脑卒中急性期同型半胱氨酸（homocysteine，Hcy）水平，观察其与卒中类型、病变部位、病变程度的相关性，为临床脑卒中的预防和治疗提供理论依据。