原创力文档a case-control study of autism and mumps-measles-rubella vaccination using the general practice research database design and methodology孤独症的病例对照研究和-麻疹疫苗接种使用惯例研究数据库设计和方法.pdfVIP
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a case-control study of autism and mumps-measles-rubella vaccination using the general practice research database design and methodology孤独症的病例对照研究和-麻疹疫苗接种使用惯例研究数据库设计和方法
BMC Public Health (2001) 1:2 /1471-2458/1/2
BMC Public Health (2001) 1:2
Case control study
A case-control study of autism and mumps-measles-rubella
vaccination using the general practice research database: design
and methodology
1 2 3 2
Liam Smeeth* , Andrew J Hall , Eric Fombonne , Laura C Rodrigues ,
Xiangning Huang2 and Peter G Smith2
Address: 1Department of Epidemiology and Population Health, 2Department of Infectious and Tropical Diseases London School of Hygiene
and Tropical Medicine Keppel Street, London WC1E 7HT, UK and 3 Institute of Psychiatry/Kings College London Department of Child and
Adolescent Psychiatry, MRC Child Psychiatry Unit, Denmark Hill, 16 De Crespigny Park, London SE5 8AF, UK
E-mail: Liam Smeeth* - liam.smeeth@lshtm.ac.uk; Andrew J Hall - andy.hall@lshtm.ac.uk; Eric Fombonne - e.fombonne@iop.kcl.ack.uk;
Laura C Rodrigues - laura.rodrigues@lshtm.ac.uk; Xiangning Huang - xiangning.huang@lshtm.ac.uk;
Peter G Smith - peter.smith@lshtm.ac.uk
*Corresponding author
Published: 15 February 2001 Received: 22 January 2001
Accepted: 15 February 2001
BMC Public Health 2001, 1:2
This article is available from: /1471-2458/1/2
(c) 2001 Smeeth et al, licensee BioMed Central Ltd.
Abstract
Background: An association between mumps-measles-rubella (MMR) vaccination and the onset
of symptoms typical of autism has recently been suggested. This has led to considerable concern
about the safety of the vaccine.
Methods: A matched case-control study using data derived form the United Kingdom General
Practice Research Database. Children with a
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