a comparative study of smar prediction toolssmar预测工具的比较研究.pdfVIP

BMC Bioinformatics BioMed Central Research article Open Access A comparative study of S/MAR prediction tools 1 2 2 2 Kenneth Evans , Sascha Ott , Annika Hansen , Georgy Koentges and Lorenz Wernisch*1 Address: 1School of Crystallography, Birkbeck College, Malet Street, London, WC1E 7HX, UK and 2Functional Genomics Laboratory, Wolfson Institute for Biomedical Research, University College London, The Cruciform Building, Gower Street, London WC1E 6AU, UK Email: Kenneth Evans - k.evans@mail.cryst.bbk.ac.uk; Sascha Ott - s.ott@ucl.ac.uk; Annika Hansen - a.hansen@ucl.ac.uk; Georgy Koentges - g.koentges@ucl.ac.uk; Lorenz Wernisch* - l.wernisch@mail.cryst.bbk.ac.uk * Corresponding author Published: 2 March 2007 Received: 27 July 2006 Accepted: 2 March 2007 BMC Bioinformatics 2007, 8:71 doi:10.1186/1471-2105-8-71 This article is available from: /1471-2105/8/71 © 2007 Evans et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Background: S/MARs are regions of the DNA that are attached to the nuclear matrix. These regions are known to affect substantially the expression of genes. The computer prediction of S/ MARs is a highly significant task which could contribute to our