拮氟锐对氟暴露工人排氟效果及对IL-2、IL-6血清浓度影响.doc

拮氟锐对氟暴露工人排氟效果及对IL-2、IL-6血清浓度影响 　 作者：徐增光, 邓生琼,郭怀兰,杨江林,王建洲 [摘 要] 目的:观察拮氟锐对工业氟暴露工人的防治效果。方法:选择某铝厂22名非氟暴露工人作为空白对照组（A组），44名氟暴露工人随机分为安慰剂组（B组）和服用拮氟锐药物组（C组）。测定服药前后血清氟 (F-)，尿氟(F-)、氟硼酸根离子(BF4-)浓度，以及血清白细胞介素2（IL-2）、白细胞介素6（IL-6）含量。结果:氟暴露组工人血F-、尿F-、BF4-浓度明显高于非氟暴露组，血清IL-2显著下降而IL-6显著上升；与安慰剂组（B组）相比，服用拮氟锐药物组（C组）血清F-明显下降，尿中F-、BF4-浓度明显上升，血清IL-2显著升高而IL-6显著下降。结论:拮氟锐能明显促进体内氟的排出，增强机体免疫功能，拮抗氟的免疫毒性。拮氟锐对工业氟病具有一定的防治作用。 　　[关键词] 拮氟锐;氟;白细胞介素2;白细胞介素6 　　Abstract:Objective To investigate the prevention and therapy effect of Jiefurui on the workers exposed to the fluorides. Methods Twenty-two unexposed workers were as the control (group A), 44 workers exposed to the fluorides were divided into the placebo group (group B) and the Jiefurui group (group C), the concentration of fluoride (F-) in serum , F- and tetrafluroborate (BF4-) in urine as well as the content of Interleukin-2 (IL-2), InterLeukin-6 (IL-6) in serum were determined.Results The F- concentration of workers exposed to the fluorides in serum and F-, BF4- in urine were significantly higher than that in the unexposed group. Compared to the group B workers, the concentration of F- in serum in the group C workers significantly decreased, and F- and BF4- in urine increased significantly, moreover, the content of IL-2 in serum increased, and the IL-6 decreased obviously.Conclusion The results suggested that the Jiefurui could significantly increase the excretion of urinary fluorides and tetrafluroborates, promote the immune function. Jiefurui showed the effects of antagonizing the toxicity of fluorides. 　　Key words:Jiefurui;Fluoride; Interleukin-2; Interleukin-6 　　氟可引起地方性氟病和工业性氟病，氟病的预防和治疗是我国的研究热点。目前，已有不少氟病的治疗药物研究报道，但仍缺乏疗效显著,又便于推广的抗氟药物。为此，我们研制了抗氟药物“拮氟锐”，通过氟暴露工人的试用，观察其干预效果。 　　1材料与方法 　　1.1某铝厂生产概况 　　某铝厂采用溶盐电解法炼铝，为连续插自焙槽生产，电解槽双排列，计24个槽。生产过程中，各工序以手工操作为主，机械操作为辅；防护措施以自然通风为主，机械通风为辅。电解生产的工种有电解工、阳极工、天车工和出铝工等。电解班为五班倒制，每天上午6∶00~8∶00有一个阳级班，8∶00~11∶00有一个出铝班。 　　1.2 观察对象及分组 　　选取该铝厂非接触氟人群22人作为空白对照组（A组），年龄29.7±6.1岁，工龄8.2±5.3年。另选该厂氟暴露工人44人，主要是电解车间工人，年龄30.5±5.2岁，工