母乳喂养及婴儿HCV感染关系META分析.docVIP

母乳喂养及婴儿HCV感染关系META分析 　【关键词】 肝炎,丙型；META分析；疾病传播,垂直 　　A META analysis of association between breastfeeding and risk for infant hepatitis C virus infection 　　【Abstract】 AIM: To investigate the association between breastfeeding and infant hepatitis C virus (HCV) infection. METHODS: China biological medicine database (CBMD) Founder Database, and Medline citations were surveyed to obtain literatures eligible for METAanalysis. Criteria for enrollment of published literatures for META analysis was based on the principles by Abdolmaleky HMs standard［1］. Odd ratios(OR) were calculated and summarized by fixed effect model or random effect model. The heterogeneity of OR was assessed using a χ2 test. The association was evaluated using the OR values. All data were calculated automatically with REVMAN 4.2 software. RESULTS: By searching in Medline and CBMD, 120 articles were enrolled for further identification. Thirtyseven reviews on this field were excluded. Abstracts of remaining articles were carefully read, and finally 6 articles met the enrollment standards. Results from META analysis suggested that there was not a significant association of breastfeeding with infant HCV infection with OR being 0.60 (95%CI: 0.22-1.60). CONCLUSION: Breastfeeding did not increase the risk for infant to acquire the infection of HCV. 　　【Keywords】 Hepatitis C; META analysis; disease transmission, vertical 　　【摘要】目的： 探讨母乳喂养与婴儿HCV感染的关系. 方法： 为了获取适于META分析的文献，对中国生物医学数据库、维普数据库、方正数据库、PUBMED数据库和MEDLINE进行检索. 纳入标准依据Abdolmaleky HM方法［1］. 用RevMan4.2软件对纳入文献采用固定效应模型或随机效应模型计算OR值. χ2检验每组OR值异质性. 联系的强度采用OR值进行评价. 结果： 对中国生物医学数据库和MEDLINE进行检索后共有120篇文献，37篇为综述，被舍弃. 对其余文献进行仔细阅读后，只有6篇文献符合本次研究标准. META分析OR值为0.6 (95%CI=0.22-1.60)，证实母乳喂养与婴儿HCV感染无关. 结论： 母乳喂养不是婴儿感染HCV的危险因素. 　　【关键词】 肝炎，丙型；META分析；疾病传播，垂直 　　0引言 　　 　　丙型肝炎（Hepatitis C, HC）是一个重要的公共卫生问题. 85%的成年人感染后会转化为慢性感染，20%的感染者将会发展为肝硬化，4%会演变为肝癌. HCV主要传播途径是通过血源性传播. 母婴传播是HCV流行区的主要途径［2］. 研究证实母亲HCV病毒载量、HIV共感染是婴儿HCV感染的重要因素. 由于大部分母乳都检测到了HCV RNA，母乳喂养会增加母亲与婴儿的密切接触的机会，因此有人怀疑母乳喂养可能与婴儿HCV感染有一定的关