磷酸铬加超液碘化油及化疗药超选择介入治疗中晚期肝癌临床观察.docVIP

磷酸铬加超液碘化油及化疗药超选择介入治疗中晚期肝癌临床观察 　 作者：徐晓峰，马玉波，王良金，徐品德，狄英三，沈鹰，吴斌 【摘要】 目的 探讨应用磷酸铬32CrPO4-超液碘化油(32P胶体-LUP)混悬液经肝动脉超选择栓塞介入治疗肝癌的方法和疗效。方法 采用Slendinger方法，经股动脉超插至肿瘤供血动脉，注入32P胶体-LUP混悬液和化疗药介入治疗中晚期肝癌，单次剂量1：1。结果 30例(观察组)接受32P胶体-LUP 混悬液介入栓塞治疗，对肝功能Child B级也可采用，肝功能损害不大。Child A级者其6、12、18个月生存率为85.7%、64.1%和42.8%，较常规剂量对照组高（P=0.0059lt;0.01），Child B级者其6、12、18个月生存率也有提高，分别为56.2%、31.3%、6.25%。结论 32P胶体-LUP混悬液超选择肝动脉栓塞介入治疗肝癌，疗效优于常规剂量介入治疗。所有病人均能耐受该项治疗，无严重并发症。 【关键词】 肝肿瘤 肝动脉栓塞 32P胶体治疗 Clinical study on middle/advanced stage hepatic carcinoma treated with superselective transarterial chemoembolization of colloid 32CrPO4-a Report of 30 cases 【Abstract】 Objective To evaluate the efficacy of superselective transarterial chemoembolization (TACE) with colloid 32CrPO4 for the treatment of middle/advanced stage hepatic carcinoma. Methods Seldinger method was used for superselective TACE of proper hepatic artery.A mixed suspension of colloid 32CrPO4 and chemotherapeutic agents was injected through the catheter. Results TACE with colloid 32CrPO4 was well tolerated by the treated patients whose liver function was of Child B stage，the frequency of post-treatment hepatic insufficiency was not significantly different from that of patients treatment with routine dose of lipoidol .The colloid 32CrPO4 was embolized in 30 cases，no serious complication or liver damage was found. The 6-， 12-， and 18-month survival rates of these patients in Child A stage were 85.7%，64.1%， and 42.8%， respectively， as compared to 55.7%， 30.7%， 5.7%， respectively in patients treated with routine does of lipiodol (P=0.0059 )and in Child B stage were 56.2%，31.3%，6.25%，respectively，as compared to 44.2%，15.3%，0%，respectively in patients treated with routine does of lipiodol(P＜0.05).Conclusion Superselective TACE with colloid 32CrPO4 is practically acceptable and better therapeutic effect on middle/advanced stage hepatic carcinoma .The results of treatment seems promising，severe complications were not found. 【Key words】 hepatic tumor hepa