病毒基因组学与病毒进化.PDF

病毒基因组学与 病毒进化 刘翟博士研究员 中国科学院微生物研究所 2016-6-27 新一代测序技术带来了测序成本的大大降低！！！ $100,000,000 $10,000,000 Moore’s Law $1,000,000 $100,000 $10,000 $1,000 $1,000 $100 Pathogens Genomics Pathogen infections are among the leading causes of infirmity and mortality among humans and other animals in the world. Until recently, it has been difficult to compile information to understand the generation of pathogen virulence factors as well as pathogen behaviour in a host environment. The study of Pathogenomics attempts to utilize genomic and metagenomics data gathered from high through-put technologies to understand microbe diversity and interaction as well as host-microbe interactions involved in disease states. Bacteria/Fungi/Protozoan • Causes of Genomic Diversity • Gene Loss / Genome Decay • Gene Gain/ Gene Duplication • Genome Rearrangement • Single Nucleotide Polymorphism • Analysis of Genomic Diversity • Pan-genomes and core genomes • Mobile Genetic Elements that Encode Virulence factors Virus • Causes of Genomic Diversity • Gene Loss / Genome Decay • Gene Gain/ Gene Duplication • Genome Rearrangement / Reassortment • Single Nucleotide Polymorphism • Analysis of Genomic Diversity • Pan-genomes and core genomes • Mobile Genetic Elements that Encode Virulence factors (Virus) Evolution • 进化生物学是研究生命的起源及进化的过程、 原因、机制、速率和方向的科学 • 起源（Origin ）：从哪里来？ • 进程 （Process/Route）：怎么