原创力文档a randomized controlled trial to investigate the influence of low dose radiotherapy on immune stimulatory effects in liver metastases of colorectal cancer随机对照试验研究低剂量放疗的影响在大肠癌肝转移的免疫刺激的影响.pdfVIP
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a randomized controlled trial to investigate the influence of low dose radiotherapy on immune stimulatory effects in liver metastases of colorectal cancer随机对照试验研究低剂量放疗的影响在大肠癌肝转移的免疫刺激的影响
Reissfelder et al. BMC Cancer 2011, 11:419
/1471-2407/11/419
STUDY PROTOCOL Open Access
A randomized controlled trial to investigate the
influence of low dose radiotherapy on immune
stimulatory effects in liver metastases of
colorectal cancer
1 2 1 1 1 3
Christoph Reissfelder , Carmen Timke , Hubertus Schmitz-Winnenthal , Nuh N Rahbari , Moritz Koch , Felix Klug ,
2 2 2 1 3 2
Falk Roeder , Lutz Edler , Jürgen Debus , Markus W Büchler , Philipp Beckhove , Peter E Huber and
Jürgen Weitz 1*
Abstract
Background: Insufficient migration and activation of tumor specific effector T cells in the tumor is one of the main
reasons for inadequate host anti-tumor immune response. External radiation seems to induce inflammation and
activate the immune response. This phase I/II clinical trial aims to evaluate whether low dose single fraction
radiotherapy can improve T cell associated antitumor immune response in patients with colorectal liver metastases.
Methods/Design: This is an investigator-initiated, prospective randomised, 4-armed, controlled Phase I/II trial.
Patients undergoing elective hepatic resection due to colorectal cancer liver metastasis will be enrolled in the
study. Patients will receive 0 Gy, 0.5 Gy, 2 Gy or 5 Gy radiation targeted to their liver metastasis. Radiation will be
applied by external beam radiotherapy using a 6 MV linear accelerator (Linac) with intensity modulated
radiotherapy (IMRT) technique two days prior to surgical resection. All patients admitted to the Department of
General-, Visceral-, and Transplantion Surgery, University of Heidelberg for e
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