a persistent mitochondrial deletion reduces fitness and sperm performance in heteroplasmic populations of c. elegans持续降低健身和精子线粒体删除性能的heteroplasmic秀丽隐杆线虫种群.pdfVIP
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a persistent mitochondrial deletion reduces fitness and sperm performance in heteroplasmic populations of c. elegans持续降低健身和精子线粒体删除性能的heteroplasmic秀丽隐杆线虫种群
BMC Genetics BioMed Central
Research article Open Access
A persistent mitochondrial deletion reduces fitness and sperm
performance in heteroplasmic populations of C. elegans
1 1 2
Wei-Siang Liau , Aidyl S Gonzalez-Serricchio , Cleonique Deshommes ,
1 1
Kara Chin and Craig W LaMunyon*
Address: 1Department of Biological Science, California State Polytechnic University, Pomona, CA, USA and 2School of Graduate Medical Sciences,
Barry University, Miami Shores, FL, USA
Email: Wei-Siang Liau - wliau@; Aidyl S Gonzalez-Serricchio - aidyl@;
Cleonique Deshommes - nique07@; Kara Chin - karachin20@; Craig W LaMunyon* - cwlamunyon@
* Corresponding author
Published: 29 March 2007 Received: 8 November 2006
Accepted: 29 March 2007
BMC Genetics 2007, 8:8 doi:10.1186/1471-2156-8-8
This article is available from: /1471-2156/8/8
© 2007 Liau et al; licensee BioMed Central Ltd.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0),
which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
Background: Mitochondrial DNA (mtDNA) mutations are of increasing interest due to their
involvement in aging, disease, fertility, and their role in the evolution of the mitochondrial genome.
The presence of reactive oxygen species and the near
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