a permutation-based multiple testing method for time-course microarray experimentspermutation-based多个时间进程微阵列实验的测试方法.pdfVIP

BMC Bioinformatics BioMed Central Methodology article Open Access A permutation-based multiple testing method for time-course microarray experiments 1 1,2 1,2 3,4 Insuk Sohn , Kouros Owzar , Stephen L George , Sujong Kim and Sin- Ho Jung*1,2 Address: 1Department of Biostatistics and Bioinformatics, Duke University Medical Center, Durham, North Carolina 27710, USA, 2CALGB Statistical Center, Durham, North Carolina 27705, USA, 3Skin Research Institute, AmorePacific RD Center, Yongin 449-729, Republic of Korea and 4RD Center, Komipharm International Co, LTD, Kyounggi-do 429-450, Republic of Korea Email: Insuk Sohn - insuk.sohn@; Kouros Owzar - kouros.owzar@; Stephen L George - stephen.george@; Sujong Kim - sjkim007@; Sin-Ho Jung* - sinho.jung@ * Corresponding author Published: 15 October 2009 Received: 18 March 2009 Accepted: 15 October 2009 BMC Bioinformatics 2009, 10:336 doi:10.1186/1471-2105-10-336 This article is available from: /1471-2105/10/336 © 2009 Sohn et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Background: Time-course microarray experiments are widely used to study the temporal profiles of gene expression. Sto