原创力文档a robust classifier of high predictive value to identify good prognosis patients in er-negative breast cancer一个健壮的高预测价值的分类器识别在er阴性乳腺癌患者预后良好.pdfVIP
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a robust classifier of high predictive value to identify good prognosis patients in er-negative breast cancer一个健壮的高预测价值的分类器识别在er阴性乳腺癌患者预后良好
Available online /content/10/4/R73
Vol 10 No 4 Open Access
Research article
A robust classifier of high predictive value to identify good
prognosis patients in ER-negative breast cancer
Andrew E Teschendorff1,2 and Carlos Caldas1,3
1Breast Cancer Functional Genomics Laboratory, Cancer Research UK Cambridge Research Institute, Cambridge, CB2 0RE, UK.
2Department of Oncology University of Cambridge, Li Ka-Shing Centre, Robinson Way, Cambridge CB2 0RE, UK.
3Cambridge Breast Unit, Addenbrookes Hospital, Cambridge University Hospitals NHS Foundation Trust, Hills Road, Cambridge, UK.
Corresponding author: Andrew E Teschendorff, aet21@cam.ac.uk
Received: 25 Apr 2008 Revisions requested: 7 Jul 2008 Revisions received: 15 Jul 2008 Accepted: 28 Aug 2008 Published: 28 Aug 2008
Breast Cancer Research 2008, 10:R73 (doi:10.1186/bcr2138)
This article is online at: /content/10/4/R73
© 2008 Teschendorff and Caldas; licensee BioMed Central Ltd.
This is an open access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0),
which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
Introduction Patients with primary operable oestrogen receptor Results We report the construction of a seven-gene expression
(ER) negative (-) breast cancer account for about 30% of all classifier that accurately predicts, across a training cohort of
cases and generally have a worse prognosis than ER-positive 183 ER- tumours and six independent test cohorts (a total of
(+) patients. Nevertheless, a significant proportion of ER- cases 469 ER- tumours), ER- patients of good prognosis (in test sets,
have favourable outcomes and could potentially bene
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