原创力文档a snp based linkage map of the turkey genome reveals multiple intrachromosomal rearrangements between the turkey and chicken genomes基于snp的土耳其基因组连锁图显示多个染色体内土耳其和鸡的基因组之间的重组.pdfVIP
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a snp based linkage map of the turkey genome reveals multiple intrachromosomal rearrangements between the turkey and chicken genomes基于snp的土耳其基因组连锁图显示多个染色体内土耳其和鸡的基因组之间的重组
Aslam et al. BMC Genomics 2010, 11:647
/1471-2164/11/647
RESEARCH ARTICLE Open Access
A SNP based linkage map of the turkey genome
reveals multiple intrachromosomal rearrangements
between the Turkey and Chicken genomes
1* 1 1 2
Muhammad L Aslam , John WM Bastiaansen , Richard PMA Crooijmans , Addie Vereijken ,
Hendrik-Jan Megens1, Martien AM Groenen1
Abstract
Background: The turkey (Meleagris gallopavo) is an important agricultural species that is the second largest
contributor to the world’s poultry meat production. The genomic resources of turkey provide turkey breeders with
tools needed for the genetic improvement of commercial breeds of turkey for economically important traits.
A linkage map of turkey is essential not only for the mapping of quantitative trait loci, but also as a framework to
enable the assignment of sequence contigs to specific chromosomes. Comparative genomics with chicken
provides insight into mechanisms of genome evolution and helps in identifying rare genomic events such as
genomic rearrangements and duplications/deletions.
Results: Eighteen full sib families, comprising 1008 (35 F1 and 973 F2) birds, were genotyped for 775 single
nucleotide polymorphisms (SNPs). Of the 775 SNPs, 570 were informative and used to construct a linkage map in
turkey. The final map contains 531 markers in 28 linkage groups. The total genetic distance covered by these
linkage groups is 2,324 centimorgans (cM) with the largest linkage group (81 loci) measuring 326 cM. Average
marker interval for all markers across the 28 linkage groups is 4.6 cM. Comparative mapping of turkey and chicken
revealed two inter-, and 57 intrachromosomal rearrangements between these two species.
Conclusion: Our turkey genetic m
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