原创力文档a systems biology strategy for predicting similarities and differences of drug effects evidence for drug-specific modulation of inflammation in atherosclerosis系统生物学策略预测药物效应的异同的证据还调制炎症在动脉粥样硬化.pdfVIP
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a systems biology strategy for predicting similarities and differences of drug effects evidence for drug-specific modulation of inflammation in atherosclerosis系统生物学策略预测药物效应的异同的证据还调制炎症在动脉粥样硬化
A Systems Biology Strategy for Predicting
Similarities and Differences of Drug Effects:
Evidence for Drug-specific Modulation of
Inflammation in Atherosclerosis
Kleemann et al.
Kleemann et al. BMC Systems Biology 2011, 5:125
/1752-0509/5/125 (12 August 2011)
Kleemann et al. BMC Systems Biology 2011, 5:125
/1752-0509/5/125
RESEARCH ARTICLE Open Access
A Systems Biology Strategy for Predicting
Similarities and Differences of Drug Effects:
Evidence for Drug-specific Modulation of
Inflammation in Atherosclerosis
1* 3 3 4,5 1,2 1
Robert Kleemann , Svetlana Bureeva , Ally Perlina , Jim Kaput , Lars Verschuren , Peter Y Wielinga ,
6 3 2 1
Eva Hurt-Camejo , Yuri Nikolsky , Ben van Ommen and Teake Kooistra
Abstract
Background: Successful drug development has been hampered by a limited understanding of how to translate
laboratory-based biological discoveries into safe and effective medicines. We have developed a generic method for
predicting the effects of drugs on biological processes. Information derived from the chemical structure and
experimental omics data from short-term efficacy studies are combined to predict the possible protein targets and
cellular pathways affected by drugs.
Results: Validation of the method with anti-atherosclerotic compounds (fenofibrate, rosuvastatin, LXR activator
T0901317) demonstrated a great conformity between the computationally predicted effects and the wet-lab
biochemical effects. Comparative genome-wide pathway mapping revealed that the biological drug effects were
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