原创力文档aberrant overexpression of an epithelial marker, 14-3-3σ, in a subset of hematological malignancies异常的超表达上皮标记,14-3-3σ血液恶性肿瘤的一个子集.pdfVIP
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aberrant overexpression of an epithelial marker, 14-3-3σ, in a subset of hematological malignancies异常的超表达上皮标记,14-3-3σ血液恶性肿瘤的一个子集
BMC Cancer BioMed Central
Research article Open Access
Aberrant overexpression of an epithelial marker, 14-3-3σ, in a
subset of hematological malignancies
Toru Motokura*, Yukari Nakamura and Hiroyuki Sato
Address: Department of Hematology and Oncology, Faculty of Medicine, The University of Tokyo, Tokyo, Japan
Email: Toru Motokura* - motokura@grape.med.tottori-u.ac.jp; Yukari Nakamura - ynakamura-tky@umin.ac.jp; Hiroyuki Sato - satouhi1-
tky@umin.ac.jp
* Corresponding author
Published: 25 November 2007 Received: 26 June 2007
Accepted: 25 November 2007
BMC Cancer 2007, 7:217 doi:10.1186/1471-2407-7-217
This article is available from: /1471-2407/7/217
© 2007 Motokura et al; licensee BioMed Central Ltd.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0),
which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
Background: 14-3-3σ is a p53-mediated cell-cycle inhibitor in epithelial cells. The expression of
14-3-3σ is frequently altered in cancers of epithelial origin associated with altered DNA
methylation. Since its involvement in a non-epithelial tumor is unknown, we examined 14-3-3σ
expression in patients with haematological malignancies.
Methods: We analyzed 41 hematopoietic cell lines and 129 patients with a variety of hematological
malignancies for 14-3-3σ expression with real-time RT-PCR. We also
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