accelerated partial breast irradiation technically feasible but who will benefit加速部分乳腺照射技术上可行,但谁将受益.pdfVIP

Breast Cancer Research May 2005 Vol 7 No 3 Ross Commentary Accelerated partial breast irradiation: technically feasible but who will benefit? Gillian Ross Royal Marsden Hospital and Institute of Cancer Research, London, UK Corresponding author: Gillian Ross, Gillian.ross@rmh.nhs.uk Published: 5 April 2005 Breast Cancer Research 2005, 7:110-112 (DOI 10.1186/bcr1016) This article is online at /content/7/3/110 © 2005 BioMed Central Ltd See related commentary by Keisch, page 106 [/content/7/3/106] Abstract concerns regarding long-term efficacy emerged from the Modern breast cancer radiotherapy aims to increase Early Breast Trialists overview [2], which confirmed excess uncomplicated cure rates. A priority is reduction of late effects cardiac events in left-sided breast cancers. which include chronic chest wall or breast pain, poor cosmesis, and cardiac toxicity. As breast screening detects early cancers we One approach to reducing late radiotherapy morbidity with may be able to safely restrict irradiation postlumpectomy to the WBRT has been to seek to define those patients with small, tumour bed with a margin, defining a ‘partial breast’ target volume node-negative cancers, who are most likely to have been for treatment. Differing technical approaches to partial breast irradiation are being evaluated in phase III studies with standard ‘cur