a systematic molecular circuit design method for gene networks under biochemical time delays and molecular noises基因网络系统的分子电路设计方法在生化时间延迟和分子的声音.pdfVIP

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a systematic molecular circuit design method for gene networks under biochemical time delays and molecular noises基因网络系统的分子电路设计方法在生化时间延迟和分子的声音.pdf

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a systematic molecular circuit design method for gene networks under biochemical time delays and molecular noises基因网络系统的分子电路设计方法在生化时间延迟和分子的声音

BMC Systems Biology BioMed Central Research article Open Access A systematic molecular circuit design method for gene networks under biochemical time delays and molecular noises Bor-Sen Chen and Yu-Te Chang Address: 1Lab of Control and Systems Biology, Department of Electrical Engineering, National Tsing Hua University, Hsinchu, Taiwan 30013, ROC E-mail: Bor-Sen Chen* - bschen@.tw; Yu-Te Chang - d937908@.tw *Corresponding author Published: 27 November 2008 Received: 19 June 2008 BMC Systems Biology 2008, 2:103 doi: 10.1186/1752-0509-2-103 Accepted: 27 November 2008 This article is available from: /1752-0509/2/103 © 2008 Chen and Chang; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Background: Gene networks in nanoscale are of nonlinear stochastic process. Time delays are common and substantial in these biochemical processes due to gene transcription, translation, posttranslation protein modification and diffusion. Molecular noises in gene networks come from intrinsic fluctuations, transmitted noise from upstream genes, and the global noise affecting all genes. Knowledge of molecular noise filtering and biochemical process delay compensation in gene networks is crucial to understand the signal processing in gene networks and the design of noise- tolerant and delay-robust gene cir