原创力文档adoptive transfer of il-4rα+ macrophages is sufficient to enhance eosinophilic inflammation in a mouse model of allergic lung inflammation过继转移il-4rα+巨噬细胞能充分提高嗜酸性炎症过敏性肺部炎症的小鼠模型.pdfVIP
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adoptivetransferofil-4rαmacrophagesissufficienttoenhanceeosinophilicinflammationinamousemodelofallergiclunginflammation过继转移il-4rα巨噬细胞能充分提高嗜酸性炎症过敏性肺部炎症的小鼠模型
Adoptive transfer of IL-4Rα+ macrophages is
sufficient to enhance eosinophilic inflammation
in a mouse model of allergic lung inflammation
Ford et al.
Ford et al. BMC Immunology 2012, 13:6
/1471-2172/13/6 (31 January 2012)
Ford et al. BMC Immunology 2012, 13:6
/1471-2172/13/6
RESEARCH ARTICLE Open Access
Adoptive transfer of IL-4Ra+ macrophages is
sufficient to enhance eosinophilic inflammation
in a mouse model of allergic lung inflammation
1 1 1 1 3
Andrew Q Ford , Preeta Dasgupta , Irina Mikhailenko , Elizabeth MP Smith , Nancy Noben-Trauth and
Achsah D Keegan1,2*
Abstract
Background: The IL-4 receptor a (IL-4Ra) chain has a broad expression pattern and participates in IL-4 and IL-13
signaling, allowing it to influence several pathological components of allergic lung inflammation. We previously
reported that IL-4Ra expression on both bone marrow-derived and non-bone marrow-derived cells contributed to
the severity of allergic lung inflammation. There was a correlation between the number of macrophages
expressing the IL-4Ra, CD11b, and IAd, and the degree of eosinophilia in ovalbumin challenged mice. The
engagement of the IL-4Ra by IL-4 or IL-13 is able to stimulate the alternative activation of macrophages (AAM).
The presence of AAM has been correlated with inflammatory responses to parasites and allergens. Therefore, we
hypothesized that IL-4Ra+ AAM play an active role in allergic lung inflammation. To directly determine the role of
AAM in allergic lung inflammation, M-CSF-dependent macrophages (BMM) were prepared from the bone-marrow
of IL-4Ra positive a
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