原创力文档advanced glycation end products impair the migration, adhesion and secretion potentials of late endothelial progenitor cells先进的糖化结束产品损害迁移、粘附和分泌晚期内皮祖细胞的潜力.pdfVIP
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advanced glycation end products impair the migration, adhesion and secretion potentials of late endothelial progenitor cells先进的糖化结束产品损害迁移、粘附和分泌晚期内皮祖细胞的潜力
Li et al. Cardiovascular Diabetology 2012, 11:46 CARDIO
/content/11/1/46 VASCULAR
DIABETOLOGY
ORIGINAL INVESTIGATION Open Access
Advanced glycation end products impair the
migration, adhesion and secretion potentials of
late endothelial progenitor cells
† † *
Hong Li , Xiaoyun Zhang , Xiumei Guan, Xiaodong Cui, Yuliang Wang, Hairong Chu and Min Cheng
Abstract
Background: Endothelial progenitor cells (EPCs), especially late EPCs, play a critical role in endothelial maintenance
and repair, and postnatal vasculogenesis. Advanced glycation end products (AGEs) have been shown to impair EPC
functions, such as proliferation, migration and adhesion. However, their role in the regulation of the production of
vasoactive substances in late EPCs is less well defined.
Methods: Passages of 3~5 EPCs, namely late EPCs, were cultured with different concentrations (0~500 μg/ml) of
AGEs, and the apoptosis, adhesion and migration were subsequently determined. The release of vasoactive
substances, such as stromal cell-derived factor-1 (SDF-1), nitric oxide (NO), prostaglandin I (PGI ), plasminogen
2 2
activator inhibitor-1 (PAI-1), tissue plasminogen activator (tPA), and in addition the activity of superoxide dismutase
(SOD), were evaluated by ELISA. At the same time, the gene and protein expressions of CXCR4 were assayed by
real-t
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