原创力文档acquisition of antibodies to merozoite surface protein 3 among residents of korogwe, north eastern tanzania收购裂殖子表面蛋白抗体3 korogwe居民之间,北东部的坦桑尼亚.pdfVIP
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acquisition of antibodies to merozoite surface protein 3 among residents of korogwe, north eastern tanzania收购裂殖子表面蛋白抗体3 korogwe居民之间,北东部的坦桑尼亚
Segeja et al. BMC Infectious Diseases 2010, 10:55
/1471-2334/10/55
RESEARCH ARTICLE Open Access
Acquisition of antibodies to merozoite surface
protein 3 among residents of Korogwe, north
eastern Tanzania
*
Method D Segeja , Bruno P Mmbando, Misago D Seth, John P Lusingu, Martha M Lemnge
Abstract
Background: A polymorphic malaria parasite antigen, merozoite surface protein 3 (MSP3), is among the blood
stage malaria vaccine candidates. It is believed to induce immunity through cytophilic antibodies that disrupt the
process of erythrocytes invasion by merozoites. This study aimed at assessing natural acquisition of antibodies to
MSP3 in individuals living in an area with different malaria transmission intensity in preparation for malaria vaccine
trials.
Methods: The study was conducted in individuals aged 0-19 years from villages located in lowland, intermediate
and highland strata in Korogwe district, northeastern Tanzania. Blood samples from 492 study participants were
collected between May and June 2006 for malaria diagnosis and immunological investigations. Reactivity of MSP3
to different types of antibodies (immunoglobulin M, G and IgG subclass 1 and 3) were analysed by Enzyme Linked
ImmunoSorbent Assay (ELISA).
Results: Malaria parasite prevalence was higher in the lowland (50%) compared to the intermediate (23.1%) and
highland (9.8%) strata. Immunogloblin G subclasses 1 and 3 (IgG1 IgG3), total IgG and IgM were found to
increase with increasing age. IgG3 levels were significantly higher than IgG1 (p 0.001). Furthermore, Plasmodium
falciparum infection was associated with higher IgG3 levels (p = 0.008). Adjusting by strata and age in individuals
who had positive blood smears, both IgG and IgM were associated with parasite density, whereby IgG levels
decreased by 0.227 (95%CI: 0.064
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