a transcriptional response to wnt protein in human embryonic carcinoma cells转录反应wnt蛋白质在人类胚胎细胞癌.pdfVIP

BMC Developmental Biology BioMed Central BMC Developmental Biology x 2002, 2 Research article A transcriptional response to Wnt protein in human embryonic carcinoma cells Jennifer Willert1,3, Mirjam Epping1,4, Jonathan R Pollack2,5, 2 1 Patrick O Brown and Roel Nusse* Address: 1Department of Developmental Biology, Howard Hughes Medical Institute, Stanford University, Stanford, CA 94305 USA, 2Department of Biochemistry, Howard Hughes Medical Institute, Stanford University, Stanford, CA 94305 USA, 3Childrens Hospital, San Diego, USA, 4Netherlands Cancer Institute, Amsterdam, The Netherlands and 5Dept of Pathology, Stanford University, CA, USA E-mail: Jennifer Willert - jennifer.willert@; Mirjam Epping - epping_m_t_@; Jonathan R Pollack - pollack1@; Patrick O Brown - pbrown@; Roel Nusse* - rnusse@ *Corresponding author Published: 2 July 2002 Received: 30 May 2002 Accepted: 2 July 2002 BMC Developmental Biology 2002, 2:8 This article is available from: /1471-213X/2/8 © 2002 Willert et al; licensee BioMed Central Ltd. This article is published in Open Access: verbatim copying and redistribution of this article are permitted in all media for any non-commercial purpose, provided this notice is preserved along with the articles original URL. Abstract Background: Wnt signaling is implicated in many developmental decisions, including stem cell control, as well as in cancer. There are relatively few target genes known of the Wnt pathway. Results: We have identified target genes of Wnt signaling using microarray technology and human