a trial assessing n-3 as treatment for injury-induced cachexia (atlantic trial) does a moderate dose fish oil intervention improve outcomes in older adults recovering from hip fracture试验评估n - 3作为治疗创伤性恶病质(大西洋试验)中等剂量鱼油干预改善老年人髋部骨折恢复的结果.pdfVIP

Miller et al. BMC Geriatrics 2010, 10:76 /1471-2318/10/76 STUDY PROTOCOL Open Access A trial assessing N-3 as treatment for injury- induced cachexia (ATLANTIC trial): does a moderate dose fish oil intervention improve outcomes in older adults recovering from hip fracture? 1* 2 1 1 3 4 4 Michelle D Miller , Alison Yaxley , Anthony Villani , Lynne Cobiac , Robert Fraser , Leslie Cleland , Michael James , Maria Crotty2 Abstract Background: Proximal femoral fractures are associated with increased morbidity and mortality. Pre-existing malnutrition and weight loss amongst this patient group is of primary concern, with conventional nutrition support being largely ineffective. The inflammatory response post proximal femoral fracture surgery and the subsequent risk of cachexia may explain the inability of conventional high energy high protein management to produce an anabolic response amongst these patients. Omega-3 fatty acids derived from fish oils have been extensively studied for their anti-inflammatory benefits. Due to their anti-inflammatory properties, the benefit of fish oil combined with individualized nutrition support amongst proximal femoral fracture patients post surgery is an attractive potential therapeutic strategy. The aim of the ATLANTIC trial is to assess the potential benefits of an anti- inflammatory dose of fish oil within the context of a 12 week individualised nutrition program, commencing seven days post proximal femoral fracture surgery. Methods/Design: This randomized controlled, double blinded trial, will recruit 150 community dwelling elderly patients aged ≥65 years, within seven days of surgery for proximal femoral fracture. Participants will be randomly allocated