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a topological algorithm for identification of structural domains of proteins拓扑算法识别蛋白质的结构域
BMC Bioinformatics BioMed Central
Research article Open Access
A topological algorithm for identification of structural domains of
proteins
Frank Emmert-Streib*1,3 and Arcady Mushegian1,2
Address: 1Stowers Institute for Medical Research, 1000 E. 50th Street, Kansas City, MO 64110, USA, 2University of Kansas Medical Center, Kansas
City, KS 66160, USA and 3University of Washington, 1705 NE Pacific St, Box 355065, Seattle WA 98195-5065, USA
Email: Frank Emmert-Streib* - v@; Arcady Mushegian - arm@
* Corresponding author
Published: 3 July 2007 Received: 28 February 2007
Accepted: 3 July 2007
BMC Bioinformatics 2007, 8:237 doi:10.1186/1471-2105-8-237
This article is available from: /1471-2105/8/237
© 2007 Emmert-Streib and Mushegian; licensee BioMed Central Ltd.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0),
which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
Background: Identification of the structural domains of proteins is important for our understanding of
the organizational principles and mechanisms of protein folding, and for insights into protein function and
evolution. Algorithmic methods of dissecting protein of known structure into domains developed so far
are based on an examination of multiple geometrical, physical and topological features. Successful as many
of these approaches are, they employ a lot of heuristics, and it is not clear whether they
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