akt2 a role in breast cancer metastasisakt2乳腺癌转移.pdfVIP

Available online /content/6/1/55 Commentary Akt2: a role in breast cancer metastasis Noan-Minh Chau and Margaret Ashcroft Cancer Research UK Centre for Cancer Therapeutics, Institute of Cancer Research, Sutton, Surrey, UK Corresponding author: Margaret Ashcroft (e-mail: margaret.ashcroft@icr.ac.uk) Published: 4 November 2003 Breast Cancer Res 2004, 6:55-57 (DOI 10.1186/bcr739) © 2004 BioMed Central Ltd (Print ISSN 1465-5411; Online ISSN 1465-542X) Abstract Metastasis in breast cancer significantly increases morbidity and mortality. The 5-year survival rate reduces from 90% for localised disease to about 20% once metastasis has taken place. The phosphoinositide 3-kinase/Akt signalling pathway has an important role in cell motility, invasion and metastasis. However, the precise contribution of the Akt kinase family members, Akt1, Akt2 and Akt3, in mediating these processes is unclear. The possibility that they have distinct functions in tumour progression is particularly interesting. Keywords: Akt2, invasion, metastasis, phosphoinositide 3-kinase, PTEN Introduction role of Akt1 in cell survival and proliferation, the study by A recent study by Arboleda and colleagues has addressed Arboleda and colleagues [1] has highlighted the impor- the role of Akt2 in metastasis with the use of human breast tance of Akt2 in metastasis in breast and ovarian cancer and ovarian cancer cell lines [1]. This study revealed that cells. This work reinforces the idea that members of the Akt Akt2 was sufficient to mediat