altered cardiac rhythm in infants with bronchiolitis and respiratory syncytial virus infection改变心脏节律在婴儿毛细支气管炎和呼吸道合胞病毒感染.pdfVIP

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altered cardiac rhythm in infants with bronchiolitis and respiratory syncytial virus infection改变心脏节律在婴儿毛细支气管炎和呼吸道合胞病毒感染.pdf

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altered cardiac rhythm in infants with bronchiolitis and respiratory syncytial virus infection改变心脏节律在婴儿毛细支气管炎和呼吸道合胞病毒感染

Esposito et al. BMC Infectious Diseases 2010, 10:305 /1471-2334/10/305 RESEARCH ARTICLE Open Access Altered cardiac rhythm in infants with bronchiolitis and respiratory syncytial virus infection 1* 2 1 2 1 1 Susanna Esposito , Patrizia Salice , Samantha Bosis , Silvia Ghiglia , Elena Tremolati , Claudia Tagliabue , 1 3 4,5 1 1 Laura Gualtieri , Paolo Barbier , Carlotta Galeone , Paola Marchisio , Nicola Principi Abstract Background: Although the most frequent extra-pulmonary manifestations of respiratory syncytial virus (RSV) infection involve the cardiovascular system, no data regarding heart function in infants with bronchiolitis associated with RSV infection have yet been systematically collected. The aim of this study was to verify the real frequency of heart involvement in patients with bronchiolitis associated with RSV infection, and whether infants with mild or moderate disease also risk heart malfunction. Methods: A total of 69 otherwise healthy infants aged 1-12 months with bronchiolitis hospitalised in standard wards were enrolled. Pernasal flocked swabs were performed to collect specimens for the detection of RSV by real- time polymerase chain reaction, and a blood sample was drawn to assess troponin I concentrations. On the day of admission, all of the infants underwent 24-hour Holter ECG monitoring and a complete heart evaluation with echocardiography. Patients were re-evaluated by investigators blinded to the etiological and cardiac findings four weeks after enrolment. Results: Regardless of their clinical presentation, sinoatrial blocks were identified in 26/34 RSV-positive