原创力文档altered expression of micrornas in the myocardium of rats with acute myocardial infarction改变小分子核糖核酸的表达与急性心肌梗死大鼠的心肌.pdfVIP
- 1、原创力文档（book118）网站文档一经付费（服务费），不意味着购买了该文档的版权，仅供个人/单位学习、研究之用，不得用于商业用途，未经授权，严禁复制、发行、汇编、翻译或者网络传播等，侵权必究。。
- 2、本站所有内容均由合作方或网友上传，本站不对文档的完整性、权威性及其观点立场正确性做任何保证或承诺！文档内容仅供研究参考，付费前请自行鉴别。如您付费，意味着您自己接受本站规则且自行承担风险，本站不退款、不进行额外附加服务；查看《如何避免下载的几个坑》。如果您已付费下载过本站文档，您可以点击 这里二次下载。
- 3、如文档侵犯商业秘密、侵犯著作权、侵犯人身权等，请点击“版权申诉”（推荐），也可以打举报电话：400-050-0827(电话支持时间：9:00-18:30)。
- 4、该文档为VIP文档，如果想要下载，成为VIP会员后，下载免费。
- 5、成为VIP后，下载本文档将扣除1次下载权益。下载后，不支持退款、换文档。如有疑问请联系我们。
- 6、成为VIP后，您将拥有八大权益，权益包括：VIP文档下载权益、阅读免打扰、文档格式转换、高级专利检索、专属身份标志、高级客服、多端互通、版权登记。
- 7、VIP文档为合作方或网友上传，每下载1次， 网站将根据用户上传文档的质量评分、类型等，对文档贡献者给予高额补贴、流量扶持。如果你也想贡献VIP文档。上传文档
查看更多
altered expression of micrornas in the myocardium of rats with acute myocardial infarction改变小分子核糖核酸的表达与急性心肌梗死大鼠的心肌
Shi et al. BMC Cardiovascular Disorders 2010, 10:11
/1471-2261/10/11
RESEARCH ARTICLE Open Access
Altered expression of microRNAs in the
myocardium of rats with acute myocardial
infarction
Bing Shi1,2,3, Yanhong Guo1,3, Juan Wang3,4*, Wei Gao1,3*
Abstract
Background: MicroRNAs(miRNAs) are important cellular components and their dysfunction is associated with
various diseases. Acute myocardial infarction (AMI) is one of the most serious cardiovascular diseases. Although
several miRNAs are reported to be associated with AMI, more novel miRNAs are needed to further investigate and
improve certainty
Methods: We applied a well-established acute myocardial infarction rat model and performed miRNAs microarray
experiments upon the myocardium tissue of rats with AMI and under sham control. We identified the differentially
expressed miRNAs and analyzed the function of miRNA targets, transcription factors, and host genes based on
bioinformatics.
Results: As a result, the levels of expression of seventeen miRNAs significantly deregulated, of which four miRNAs
were further validated by qRT-PCR. In addition, we observed that the transcription factors, targets, and host genes
of these deregulated miRNAs are enriched in cardiovascular-related functions.
Conclusion: We found that the miRNAs expression level altered in rats with AMI and differentially expressed
miRNAs may be novel biomarkers of AMI.
Background miR-29 family[11], were reported to be deregulated in
MicroRNAs (miRNAs) are small non-coding RNAs that myocardial infarction. However, considering the com-
represent one of the most important cellular compo- plex genetic variants in AMI, further investigation is
nents. Increasing evidence indicates that miRN
您可能关注的文档
- affordability, availability and acceptability barriers to health care for the chronically ill longitudinal case studies from south africa可购性、可用性和可接受性壁垒慢性病患者的医疗保健纵向案例研究来自南非.pdf
- aflp analysis reveals a lack of phylogenetic structure within solanum section petota妊娠的分析揭示了在茄属植物部分petota缺乏系统的结构.pdf
- advanced glycation end products induce chemokinecytokine production via activation of p38 pathway and inhibit proliferation and migration of bone marrow mesenchymal stem cells先进的糖化结束产品诱导chemokinecytokine生产通过p38通路的激活和抑制骨髓间充质干细胞的增殖和迁移.pdf
- afp, pivkaii, gp3, scca-1 and follisatin as surveillance biomarkers for hepatocellular cancer in non-alcoholic and alcoholic fatty liver disease法新社、pivkaii gp3、scca-1 follisatin作为监测生物标志物在酒精和酒精脂肪肝肝细胞癌症.pdf
- affymapsdetector a software tool to characterize affymetrix genechip？ expression arrays with respect to snpsaffymapsdetector软件工具来描述affymetrix genechip 表达阵列对snp.pdf
- africa and the global carbon cycle非洲和全球碳循环.pdf
- affinity-based enrichment strategies to assay methyl-cpg binding activity and dna methylation in early xenopus embryosaffinity-based浓缩策略分析methyl-cpg绑定活动和dna甲基化在非洲爪蟾蜍早期胚胎.pdf
- afferent activity to necklace glomeruli is dependent on external stimuli项链肾小球传入活动是依赖外部刺激.pdf
- african meningitis belt pneumococcal disease epidemiology indicates a need for an effective serotype 1 containing vaccine, including for older children and adults非洲脑膜炎带肺炎球菌病流行病学显示需要一个有效的血清型1包含疫苗,包括年龄较大的儿童和成人.pdf
- aegepuci a database of gene expression in the dengue vector mosquito, aedes aegyptiaegepuci数据库登革热病媒蚊子的基因表达,埃及伊蚊.pdf
- altered gene expression in highly purified enterocytes from patients with active coeliac disease改变基因表达的高纯度肠上皮细胞活跃的腹腔疾病患者.pdf
- altered efficacy of at1r-targeted treatment after spontaneous cancer cell-at1r upregulation改变功效at1r-targeted治疗后自发癌症cell-at1r upregulation.pdf
- alterations of the extracellular matrix in ovarian cancer studied by second harmonic generation imaging microscopy细胞外基质的改变卵巢癌研究的二次谐波发生成像显微镜.pdf
- altered metabolism in cancer改变代谢在癌症.pdf
- altered gene expression changes in arabidopsis leaf tissues and protoplasts in response to plum pox virus infection改变基因表达变化的拟南芥叶组织和原生质体在回应李子痘病毒感染.pdf
- altered expression of mitochondrial and extracellular matrix genes in the heart of human fetuses with chromosome 21 trisomy改变线粒体和细胞外基质基因的表达在人类胎儿的心脏21号染色体三染色体细胞.pdf
- altered localisation of the copper efflux transporters atp7a and atp7b associated with cisplatin resistance in human ovarian carcinoma cells改变本地化的铜流出运输车atp7a和atp7b与顺铂耐药性在人类卵巢细胞癌.pdf
- altered expression pattern of integrin alphavbeta3 correlates with actin cytoskeleton in primary cultures of human breast cancer改变表达式模式的整合素alphavbeta3与肌动蛋白细胞骨架在人类乳腺癌的主要文化.pdf
- altered expression patterns of lipid metabolism genes in an animal model of hcv core-related, nonobese, modest hepatic steatosis改变脂质代谢基因的表达模式在丙肝病毒core-related动物模型,nonobese,适度的肝脂肪变性.pdf
- altered myocardial substrate metabolism is associated with myocardial dysfunction in early diabetic cardiomyopathy in rats studies using positron emission tomography改变心肌基质代谢与心肌功能障碍在糖尿病心肌病大鼠早期研究使用正电子发射断层扫描.pdf
文档评论（0）