an approach to evaluate the topological significance of motifs and other patterns in regulatory networks一种方法来评估拓扑意义的主题和其他模式的监管网络.pdfVIP

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an approach to evaluate the topological significance of motifs and other patterns in regulatory networks一种方法来评估拓扑意义的主题和其他模式的监管网络.pdf

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an approach to evaluate the topological significance of motifs and other patterns in regulatory networks一种方法来评估拓扑意义的主题和其他模式的监管网络

BMC Systems Biology BioMed Central Methodology article Open Access An approach to evaluate the topological significance of motifs and other patterns in regulatory networks 1 1,2 1 Björn Goemann , Edgar Wingender and Anatolij P Potapov* Address: 1Department of Bioinformatics, Medical School, Georg August University of Göttingen, Goldschmidtstrasse 1, D-37077 Göttingen, Germany and 2BIOBASE GmbH, Halchtersche Strasse 33, D-38304 Wolfenbüttel, Germany Email: Björn Goemann - bjoern.goemann@bioinf.med.uni-goettingen.de; Edgar Wingender - e.wingender@med.uni-goettingen.de; Anatolij P Potapov* - anatolij.potapov@bioinf.med.uni-goettingen.de * Corresponding author Published: 19 May 2009 Received: 28 October 2008 Accepted: 19 May 2009 BMC Systems Biology 2009, 3:53 doi:10.1186/1752-0509-3-53 This article is available from: /1752-0509/3/53 © 2009 Goemann et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Background: The identification of network motifs as statistically over-represented topological patterns has become one of the most promising topics in the analysis of complex networks. The main focus is commonly made on how they operate by means of their in