algorithms for incorporating prior topological information in hmms application to transmembrane proteins算法将之前拓扑信息摘要应用程序跨膜蛋白.pdfVIP

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algorithms for incorporating prior topological information in hmms application to transmembrane proteins算法将之前拓扑信息摘要应用程序跨膜蛋白.pdf

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algorithms for incorporating prior topological information in hmms application to transmembrane proteins算法将之前拓扑信息摘要应用程序跨膜蛋白

BMC Bioinformatics BioMed Central Methodology article Open Access Algorithms for incorporating prior topological information in HMMs: application to transmembrane proteins Pantelis G Bagos, Theodore D Liakopoulos and Stavros J Hamodrakas* Address: Department of Cell Biology and Biophysics, Faculty of Biology, University of Athens, Athens 157 01, Greece Email: Pantelis G Bagos - pbagos@biol.uoa.gr; Theodore D Liakopoulos - liakop@biol.uoa.gr; Stavros J Hamodrakas* - shamodr@biol.uoa.gr * Corresponding author Published: 05 April 2006 Received: 07 January 2006 Accepted: 05 April 2006 BMC Bioinformatics 2006, 7:189 doi:10.1186/1471-2105-7-189 This article is available from: /1471-2105/7/189 © 2006 Bagos et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Background: Hidden Markov Models (HMMs) have been extensively used in computational molecular biology, for modelling protein and nucleic acid sequences. In many applications, such as transmembrane protein topology prediction, the incorporation of limited amount of information regarding the topology, arising from biochemical experiments, has been proved a very useful strategy that increased remarkably the performance of even the top-scoring methods. However,