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adipocytokine levels mark endothelial function in normotensive individualsadipocytokine水平标记内皮功能在血压正常的人.pdf

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adipocytokine levels mark endothelial function in normotensive individualsadipocytokine水平标记内皮功能在血压正常的人

Solini et al. Cardiovascular Diabetology 2012, 11:103 CARDIO /content/11/1/103 VASCULAR DIABETOLOGY ORIGINAL INVESTIGATION Open Access Adipocytokine levels mark endothelial function in normotensive individuals * Anna Solini , Francesco Stea, Eleonora Santini, Rosa Maria Bruno, Emiliano Duranti, Stefano Taddei and Lorenzo Ghiadoni Abstract Background: Endothelial dysfunction is an independent risk factor for cardiovascular events. Inflammatory mediators released by the adipose tissue can lead to local insulin resistance and endothelial dysfunction. This study addressed the relationship of adipocytokines with endothelial function and blood pressure. Methods: In 92 newly diagnosed, drug-naïve essential hypertensive patients (HT, mean age 49 yrs) without organ damage and 66 normotensive subjects (NT, mean age 47 yrs), by an automated system, we measured endothelium-dependent and -independent vasodilation as brachial artery flow-mediated dilation before and after administration of glyceryl-trinitrate. Retinol binding protein-4 (RBP4) and resistin levels were determined by ELISA and RIA, respectively. Oxidative stress was evaluated by measuring serum malondyaldehyde (MDA). Results: Flow-mediated dilation was significantly (p = 0.03) lower in HT (5.3 ± 2.6%) than NT (6.1 ± 3.1%), while response to glyceryl-trinitrate (7.5 ± 3.7% vs 7.9 ± 3.4%) was similar. RBP4 (60.6 ± 25.1 vs 61.3 ± 25.9 μg/ml), resistin (18.8 ± 5.3 vs 19.9 ± 6.1 ng/ml) and MDA levels (2.39 ± 1.26 vs 2.08 ± 1.17 nmol/ml) were not different in HT and NT. RBP4 (r = −0.25