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BMC Cardiovascular Disorders BioMed Central Research article Open Access Accuracy of popular automatic QT Interval algorithms assessed by a Gold Standard and comparison with a Novel method: computer simulation study Anthony Charles Hunt* Address: PSI HeartSignals Ltd, Institute of Medical Technology, Glasgow Technology Park, PO Box 7043, Glasgow G44 9AB. UK Email: Anthony Charles Hunt* - tony.hunt@psiheartsignals.co.uk * Corresponding author Published: 26 September 2005 Received: 12 May 2005 Accepted: 26 September 2005 BMC Cardiovascular Disorders 2005, 5:29 doi:10.1186/1471-2261-5-29 This article is available from: /1471-2261/5/29 © 2005 Hunt; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Background: Accurate measurement of the QT interval is very important from a clinical and pharmaceutical drug safety screening perspective. Expert manual measurement is both imprecise and imperfectly reproducible, yet it is used as the reference standard to assess the accuracy of current automatic computer algorithms, which thus produce reproducible but incorrect measurements of the QT interval. There is a scientific imperative to evaluate the most commonly used algorithms with an accurate and objective gold standard and investig