原创力文档a systems biology approach to investigate the effect of ph-induced gene regulation on solvent production by clostridium acetobutylicum in continuous culture系统生物学的方法研究的影响ph-induced acetobutylicum梭状芽胞杆菌基因调控溶剂生产的连续的文化.pdfVIP
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a systems biology approach to investigate the effect of ph-induced gene regulation on solvent production by clostridium acetobutylicum in continuous culture系统生物学的方法研究的影响ph-induced acetobutylicum梭状芽胞杆菌基因调控溶剂生产的连续的文化
Haus et al. BMC Systems Biology 2011, 5:10
/1752-0509/5/10
RESEARCH ARTICLE Open Access
A systems biology approach to investigate the
effect of pH-induced gene regulation on solvent
production by Clostridium acetobutylicum in
continuous culture
1† 2*† 1 3 3 3
Sylvia Haus , Sara Jabbari , Thomas Millat , Holger Janssen , Ralf-Jörg Fischer , Hubert Bahl ,
John R King2, Olaf Wolkenhauer1,4
Abstract
Background: Clostridium acetobutylicum is an anaerobic bacterium which is known for its solvent-producing
capabilities, namely regarding the bulk chemicals acetone and butanol, the latter being a highly efficient biofuel.
For butanol production by C. acetobutylicum to be optimized and exploited on an industrial scale, the effect of
pH-induced gene regulation on solvent production by C. acetobutylicum in continuous culture must be understood
as fully as possible.
Results: We present an ordinary differential equation model combining the metabolic network governing solvent
production with regulation at the genetic level of the enzymes required for this process. Parameterizing the model
with experimental data from continuous culture, we demonstrate the influence of pH upon fermentation products:
at high pH (pH 5.7) acids are the dominant product while at low pH (pH 4.5) this switches to solvents. Through
steady-state analyses of the model we focus our investigations on how alteration in gene expression of C.
acetobutylicum could be exploited to increase butanol yield in a continuous culture fermentation.
Conclusions: Incorporating gene regulation into the model of solvent production by C. acetobutylicum enables an
accurate representation of the pH-induced switch to solvent production to be obtained and theoretical
inv
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