原创力文档a simple principle concerning the robustness of protein complex activity to changes in gene expression鲁棒性的一个简单原则蛋白质基因表达的变化复杂的活动.pdfVIP
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a simple principle concerning the robustness of protein complex activity to changes in gene expression鲁棒性的一个简单原则蛋白质基因表达的变化复杂的活动
BMC Systems Biology BioMed Central
Research article Open Access
A simple principle concerning the robustness of protein complex
activity to changes in gene expression
Jennifer I Semple†1, Tanya Vavouri†1 and Ben Lehner*1,2
Address: 1EMBL-CRG Systems Biology Unit, Centre for Genomic Regulation (CRG), UPF, Dr. Aiguader 88, Barcelona 08003, Spain and 2Institució
Catalana de Recerca i Estudis Avançats (ICREA), Centre for Genomic Regulation, UPF, Dr. Aiguader 88, Barcelona 08003, Spain
Email: Jennifer I Semple - jennifer.semple@crg.es; Tanya Vavouri - tanya.vavouri@crg.es; Ben Lehner* - ben.lehner@crg.es
* Corresponding author †Equal contributors
Published: 2 January 2008 Received: 3 September 2007
Accepted: 2 January 2008
BMC Systems Biology 2008, 2:1 doi:10.1186/1752-0509-2-1
This article is available from: /1752-0509/2/1
© 2008 Semple et al; licensee BioMed Central Ltd.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0),
which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
Background: The functions of a eukaryotic cell are largely performed by multi-subunit protein
complexes that act as molecular machines or information processing modules in cellular networks.
An important problem in systems biology is to understand how, in general, these molecular
machines respond to perturbations.
Results: In yeast, genes that inhibi
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