a simple method for statistical analysis of intensity differences in microarray-derived gene expression data一个简单的统计分析方法microarray-derived强度差异基因表达数据.pdfVIP
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a simple method for statistical analysis of intensity differences in microarray-derived gene expression data一个简单的统计分析方法microarray-derived强度差异基因表达数据
BMC Biotechnology BioMed Central
BMC Biotechnology :8
2001,
1
Methodology article
A simple method for statistical analysis of intensity differences in
microarray-derived gene expression data
1 2
Alexander Kamb* and Mani Ramaswami
Address: 1Arcaris, Inc. (Currently Deltagen Proteomics, Inc.) Salt Lake City, UT USA and 2Dept of Molecular and Cell Biology and ARL Division
of Neurobiology University of Arizona Tucson, AZ USA
E-mail: Alexander Kamb* - kamb@; Mani Ramaswami - mani@
*Corresponding author
Published: 2 October 2001 Received: 21 July 2001
Accepted: 2 October 2001
BMC Biotechnology 2001, 1:8
This article is available from: /1472-6750/1/8
© 2001 Kamb and Ramaswami; licensee BioMed Central Ltd. Verbatim copying and redistribution of this article are permitted in any medium for any
non-commercial purpose, provided this notice is preserved along with the articles original URL. For commercial use, contact info@
Abstract
Background: Microarray experiments offer a potent solution to the problem of making and
comparing large numbers of gene expression measurements either in different cell types or in the
same cell type under different conditions. Inferences about the biological relevance of observed
changes in expression depend on the statistical significance of the changes. In lieu of many replicates
with which to determine accurate intensity means and variances, reliable estimates of statistical
significance remain problematic. Without
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