原创力文档a systems biology approach to analyse leaf carbohydrate metabolism in arabidopsis thaliana系统生物学的方法来分析在拟南芥叶片碳水化合物代谢.pdfVIP
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a systems biology approach to analyse leaf carbohydrate metabolism in arabidopsis thaliana系统生物学的方法来分析在拟南芥叶片碳水化合物代谢
Henkel et al. EURASIP Journal on Bioinformatics and Systems Biology 2011, 2011:2
/content/2011/1/2
RESEARCH Open Access
A systems biology approach to analyse leaf
carbohydrate metabolism in Arabidopsis thaliana
1† 2*† 2 3 1 1
Sebastian Henkel , Thomas Nägele , Imke Hörmiller , Thomas Sauter , Oliver Sawodny , Michael Ederer and
Arnd G Heyer2
Abstract
Plant carbohydrate metabolism comprises numerous metabolite interconversions, some of which form cycles of
metabolite degradation and re-synthesis and are thus referred to as futile cycles. In this study, we present a
systems biology approach to analyse any possible regulatory principle that operates such futile cycles based on
experimental data for sucrose (Scr) cycling in photosynthetically active leaves of the model plant Arabidopsis
thaliana. Kinetic parameters of enzymatic steps in Scr cycling were identified by fitting model simulations to
experimental data. A statistical analysis of the kinetic parameters and calculated flux rates allowed for estimation of
the variability and supported the predictability of the model. A principal component analysis of the parameter
results revealed the identifiability of the model parameters. We investigated the stability properties of Scr cycling
and found that feedback inhibition of enzymes catalysing metabolite interconversions at different steps of the
cycle have differential influence on stability. Applying this observation to futile cycling of Scr in leaf cells points to
the enzyme hexokinase as an important regulator, while the step of Scr degradation by invertases appears
subordinate.
Keywords: Systems biology, carbohydrate metabolism, Arabidopsis thaliana,
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