原创力文档accuracy of perfusion mri with high spatial but low temporal resolution to assess invasive breast cancer response to neoadjuvant chemotherapy a retrospective study灌注磁共振成像精度高的空间但低时间分辨率评估侵袭性乳腺癌新辅助化疗反应一个回顾性研究.pdfVIP
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accuracy of perfusion mri with high spatial but low temporal resolution to assess invasive breast cancer response to neoadjuvant chemotherapy a retrospective study灌注磁共振成像精度高的空间但低时间分辨率评估侵袭性乳腺癌新辅助化疗反应一个回顾性研究
de Bazelaire et al. BMC Cancer 2011, 11:361
/1471-2407/11/361
RESEARCH ARTICLE Open Access
Accuracy of perfusion MRI with high spatial but
low temporal resolution to assess invasive breast
cancer response to neoadjuvant chemotherapy:
a retrospective study
1* 1 2 3 4
Cédric de Bazelaire , Raphael Calmon , Isabelle Thomassin , Clément Brunon , Anne-Sophie Hamy ,
3 3 4 3 3 1
Laure Fournier , Daniel Balvay , Marc Espié , Nathalie Siauve , Olivier Clément , Eric de Kerviler and
Charles-André Cuénod3
Abstract
Background: To illustrate that Breast-MRI performed in high spatial resolution and low temporal resolution
(1 minute) allows the measurement of kinetic parameters that can assess the final pathologic response to
neoadjuvant chemotherapy in breast cancer.
Methods: Breast-MRI was performed in 24 women before and after treatment. Eight series of 1.11 minute-duration
were acquired with a sub-millimeter spatial resolution. Transfer constant (Ktrans) and leakage space (V ) were
e
calculated using measured and theoretical Arterial Input Function (AIF). Changes in kinetic parameters after
treatment obtained with both AIFs were compared with final pathologic response graded in non-responder (
50% therapeutic effect), partial-responder ( 50% therapeutic effect) and complete responder. Accuracies to identify
non-responders were compared with receiver operating characteristic curves.
Results: With measured-AIF, changes in kinetic parameters measured after treatment were in agreement
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