an update on the strategies in multicomponent activity monitoring within the phytopharmaceutical field一个更新策略的多组分phytopharmaceutical领域内的活动监视.pdfVIP

Gostner et al. BMC Complementary and Alternative Medicine 2012, 12:18 /1472-6882/12/18 DEBATE Open Access An update on the strategies in multicomponent activity monitoring within the phytopharmaceutical field 1 1 1 2 1* Johanna M Gostner , Oliver A Wrulich , Marcel Jenny , Dietmar Fuchs and Florian Ueberall Abstract Background: To-date modern drug research has focused on the discovery and synthesis of single active substances. However, multicomponent preparations are gaining increasing importance in the phytopharmaceutical field by demonstrating beneficial properties with respect to efficacy and toxicity. Discussion: In contrast to single drug combinations, a botanical multicomponent therapeutic possesses a complex repertoire of chemicals that belong to a variety of substance classes. This may explain the frequently observed pleiotropic bioactivity spectra of these compounds, which may also suggest that they possess novel therapeutic opportunities. Interestingly, considerable bioactivity properties are exhibited not only by remedies that contain high doses of phytochemicals with prominent pharmaceutical efficacy, but also preparations that lack a sole active principle component. Despite that each individual substance within these multicomponents has a low molar fraction, the therapeutic activity of these substances is established via a potentialization of their effects through combined and simultaneous attacks on multiple molecular targets. Although beneficial properties may emerge from such a broad range of perturbations on cellular machinery, validation and/or prediction of their activity profiles is accompanied with a variety of difficulties in generic risk-benefit assessments. Thu