原创力文档analyses of murine gbp homology clusters based on in silico, in vitro and in vivo studies分析小鼠同源英镑集群基于硅片,在体外和体内研究.pdfVIP
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analyses of murine gbp homology clusters based on in silico, in vitro and in vivo studies分析小鼠同源英镑集群基于硅片,在体外和体内研究
BMC Genomics BioMed Central
Research article Open Access
Analyses of murine GBP homology clusters based on in silico, in vitro
and in vivo studies
† †
Alexandra Kresse , Carolin Konermann , Daniel Degrandi, Cornelia Beuter-
Gunia, Jan Wuerthner, Klaus Pfeffer* and Sandra Beer*
Address: Institute of Medical Microbiology and Hospital Hygiene, Heinrich-Heine-University, Universitaetsstrasse 1, 40225 Duesseldorf, Germany
Email: Alexandra Kresse - alexandra.kresse@web.de; Carolin Konermann - konerman@uni-duesseldorf.de;
Daniel Degrandi - daniel.degrandi@uni-duesseldorf.de; Cornelia Beuter-Gunia - cornelia.beuter@uni-duesseldorf.de;
Jan Wuerthner - jan.wuerthner@gmx.de; Klaus Pfeffer* - klaus.pfeffer@uni-duesseldorf.de; Sandra Beer* - sandra.beer@uni-duesseldorf.de
* Corresponding authors †Equal contributors
Published: 10 April 2008 Received: 13 December 2007
Accepted: 10 April 2008
BMC Genomics 2008, 9:158 doi:10.1186/1471-2164-9-158
This article is available from: /1471-2164/9/158
© 2008 Kresse et al; licensee BioMed Central Ltd.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0),
which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
The interactions between pathogens and hosts lead to a massive upregulation of antimicrobial host
effector molecules. Among these, the 65 kDa guanylate binding proteins (GBPs) are interesting
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