原创力文档an explanatory randomised controlled trial of a nurse-led, consultation-based intervention to support patients with adherence to taking glucose lowering medication for type 2 diabetes一个解释性的随机对照试验的护士让consultation-based干预支持患者坚持服用葡萄糖降低2型糖尿病的药物.pdfVIP
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an explanatory randomised controlled trial of a nurse-led, consultation-based intervention to support patients with adherence to taking glucose lowering medication for type 2 diabetes一个解释性的随机对照试验的护士让consultation-based干预支持患者坚持服用葡萄糖降低2型糖尿病的药物
Farmer et al. BMC Family Practice 2012, 13:30
/1471-2296/13/30
RESEARCH ARTICLE Open Access
An explanatory randomised controlled trial of a
nurse-led, consultation-based intervention to
support patients with adherence to taking
glucose lowering medication for type 2 diabetes
1* 2 3 4 2 1
Andrew Farmer , Wendy Hardeman , Dyfrig Hughes , A Toby Prevost , Youngsuk Kim , Anthea Craven ,
1 2 1 2 2 5 2
Jason Oke , Sue Boase , Mary Selwood , Ian Kellar , Jonathan Graffy , Simon Griffin , Stephen Sutton
and Ann-Louise Kinmonth2
Abstract
Background: Failure to take medication reduces the effectiveness of treatment leading to increased morbidity and
mortality. We evaluated the efficacy of a consultation-based intervention to support objectively-assessed adherence
to oral glucose lowering medication (OGLM) compared to usual care among people with type 2 diabetes.
Methods: This was a parallel group randomised trial in adult patients with type 2 diabetes and HbA 1c≥7.5% (58
mmol/mol), prescribed at least one OGLM. Participants were allocated to a clinic nurse delivered, innovative
consultation-based intervention to strengthen patient motivation to take OGLM regularly and support medicine
taking through action-plans, or to usual care. The primary outcome was the percentage of days on which the prescribed
dose of medication was taken, measured objectively over 12 weeks with an electronic medication-monitoring device
(TrackCap, Aardex, Switzerland). The primary analysis was intention-to-treat.
Results: 211 patients were randomised between July 1, 2006 and November 30, 2008 in 13 British general practic
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