ancient intron insertion sites and palindromic genomic duplication evolutionally shapes an elementally functioning membrane protein family古老的内含子插入站点和回文散播他们的基因组复制形状一个彻底功能膜蛋白家族.pdfVIP
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ancient intron insertion sites and palindromic genomic duplication evolutionally shapes an elementally functioning membrane protein family古老的内含子插入站点和回文散播他们的基因组复制形状一个彻底功能膜蛋白家族
BMC Evolutionary Biology BioMed Central
Research article Open Access
Ancient intron insertion sites and palindromic genomic duplication
evolutionally shapes an elementally functioning membrane protein
family
Motoko Tanaka-Kunishima*, Yoshihiro Ishida, Kunitaro Takahashi,
Motoo Honda and Takashi Oonuma
Address: Department of Medical Physiology, Meiji Pharmaceutical University, Noshio 2-522-1, Kiyose, Tokyo, MZC204-8588, Japan
Email: Motoko Tanaka-Kunishima* - motokokt@my-pharm.ac.jp; Yoshihiro Ishida - yishida5343@ybb.ne.jp;
Kunitaro Takahashi - mkunitar@mail.ecc.u-tokyo.ac.jp; Motoo Honda - fwjb9804@web.ne.jp;
Takashi Oonuma - takashi_ohnuma@
* Corresponding author
Published: 20 August 2007 Received: 30 November 2006
Accepted: 20 August 2007
BMC Evolutionary Biology 2007, 7:143 doi:10.1186/1471-2148-7-143
This article is available from: /1471-2148/7/143
© 2007 Tanaka-Kunishima et al; licensee BioMed Central Ltd.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0),
which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
Background: In spite of the recent accumulation of genomic data, the evolutionary pathway in the
individual genes of present-day living taxa is still elusive for most genes. Among ion channels, inward
K+ rectifier (IRK) channels are the fundamental and well-defined protein group. We analyzed the
genomic structures of this group and compared them among a phylogenetically wid
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